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S4 (Andarine) - What does it do?

Andarine/S4 What does it do?

S4 (Andarine) is a SARM (Selective Androgen Receptor Modulator) that causes increased activity at androgen cells, leading to increased protein synthesis, for treatment of conditions such as muscle wasting, osteoporosis, and benign prostatic hypertrophy.

Mechanism of action

It has a high affinity for the androgen receptor (AR) and therefore mimics the effects of testosterone. However, its effects are much stronger in muscles and bones than in reproductive organs.

Benefits

After the discovery of S4's anabolic potential, its original primary use was to develop an alternative treatment to age-related muscle wasting, osteoporosis. Aside from preserving lean body mass, it can also help improve it while decreasing body fat. Aside from that, it has very minimal impact on secondary sexual organs such as the prostate and the LDL/ HDL ratio is not affected which makes it a low cardiovascular risk.

S4 may increase bone strength and combat osteoporosis. In addition to improving bone density, it also improves muscle strength, which may help reduce the risk of falls and fractures.

S4 may aid fat loss. It can minimise LPL (lipoprotein lipase) an enzyme that causes lipid accumulation and plays a role in storing fat tissue. The AR oxidizes this adipose tissue and uses it as its preferred energy source, allowing the body to decrease excess fat at an amazing rate.

Side effects

A very uncommon side effect is "night blindness", where vision may be slightly limited during night time.

 

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